P10 Molecular cytogenetic diagnosis in 591 married couples with reproductive failures: application for genetic counseling, IVF and PGD
نویسندگان
چکیده
منابع مشابه
Preimplantation Genetic Testing: Current Status and Future Prospects
While in vitro fertilization (IVF) is most often employed as a remedy for infertility, a discussion of the field would not be complete if it did not address the application of IVF to avoid genetic disorders. IVF makes it possible to assess the genetic status of the embryo before establishing a pregnancy when couples are at risk for an affected child. Physicians in the field will benefit from be...
متن کاملPreimplantation Genetic Diagnosis (PGD)
Preimplantation genetic diagnosis (PGD) is a reproductive technology used with an in vitro fertilization (IVF) cycle to increase the potential for a successful pregnancy and delivery. The most common applications for PGD include testing for extra or missing chromosomes (aneuploidy screening), familial structural chromosome rearrangements, and diagnosis of genetic disease in couples of increased...
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Retinoblastoma is a malignant embryonal tumour of childhood arising at the expense of retinal cones. It has an incidence of 1 per 15,000 to 20,000 births. In 90% of cases, it is diagnosed before the age of 3 years. The possibility of conservative management depends on early diagnosis (Moll et al., 1996). However, although treatment strategies have advanced considerably, the visual prognosis is ...
متن کاملPreimplantation genetic diagnosis (PGD) for heritable neoplasia.
UNLABELLED Especially applicable for heritable neoplasia, preimplantation genetic diagnosis (PGD) is possible for any Mendelian disorder whose gene has been localized, whether the molecular basis is known or not. METHODS AND RESULTS PGD requires DNA from gametes (oocytes) or embryos before 6 days postconception, when implantation occurs. Approaches include 1) polar body biopsy, 2) blastomere ...
متن کاملPreimplantation Genetic Diagnosis (PGD) for chromosome rearrangements
• Chromosome rearrangements include Robertsonian and reciprocal translocations (the most common form of chromosome abnormality in humans, present in approximately 1 in 500 individuals), periand paracentric inversions, interand intra-chromosomal insertions, deletions, duplications, and complex chromosome rearrangements (CCRs). • In all cases presenting for PGD, the risk of viable abnormality sho...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2010
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)62326-7